Tissue response

Explants (Time in weeks)

Polypropylene

 

Polypropylene:anionic collagen

1

9

18

 

1

9

18

I. Ulcerated skin

(-)

(-)

3+/5

 

(-)

(-)

(-)

II. Granulation tissue

(-)

(-)

3+/5

 

(-)

(-)

(-)

III. Fibrosis

3+/5

3+/5

3+/5

 

4+/5

4+/5

4+/5

IV. Inflamm. (PI)b

(-)

2+/5

4+/5

 

3+/5

1+/5

1+/5

IV.1. Histiocytes

(-)

1+/5

2+/5

 

2+/5

1+/5

1+/5

IV.3. CGM (CE)

(-)

1+/5

2+/5

 

2+/5

1+/5

1+/5

V. Osteoid

(-)

(-)

1+/5 (PI)

 

(-)

(-)

(-)

VI. Osteoblasts

(-)

(-)

1+/5

 

(-)

(-)

1+/5

VII. Osteoclasts

(-)

(-)

(-)

 

(-)

(-)

1+/5

VII. Primary bone

(-)

(-)

(-)

 

3+/5

5+/5

2+/5

VII.1. Localization

(-)

(-)

(-)

 

PI

ETI

PI

VIII. Calcification

(-)

(-)

(-)

 

(-)

(-)

(-)

Table 1: a evaluation after the established the scale 1+/5: minimal response; 5+/5: intense response; b - CGM(CE): multinucleated giant cells (foreign body reaction); PI: near the implant; ETI: surrounding all the implant; (-) absent.