RESUMEN 99: ANOMALOUS METAPLASTIC OSSIFICATION OF ANIONIC COLLAGEN COATED POLYPROPYLENE MESH AFTER IMPLANTATION IN THE ABDOMINAL WALL. Sueli Suzigan, Gilberto Goissis*, Diderot Rodrigues Parreira, Helder Chaves, Kassim M. K. Hussain, Selma R. O. Raymundo . (Depto. Quím. Fís. Molec., Inst. Quím. São Carlos (IQSC) – Universidade de São Paulo (USP), SP, Brasil. Faculdade de Medicina de São José do Rio Preto* (FAMERP)– São José do Rio Preto, SP, Brasil. IV-CVHAP 2001 PÓSTER-E - 046 La versión electrónica completa de este trabajo podrá encontrarse on-line, una vez evaluado y aceptado, en la URL: http://conganat.uninet.edu/POSTER-E/046/ Abstract      Polymeric mesh are recently the most recommended materials for the reconstruction of the abdominal wall, with special emphasis for polypropylene mesh. This work describes the preparation, characterization and the biocompatibility studies on polypropylene mesh coated with anionic collagen or in the form of a double layer with poly (vinyl chloride), as a biomaterials for the reconstruction of the abdominal wall. Materials were characterized by electron scanning microscopy, differential scanning calorimetry and by microscopic study of their implantation in the abdominal wall of sheep for periods from 01 to 18 weeks. The results showed that the double layer of polypropyleno:poly (vinyl chloride) was the most biocompatible and less susceptible in relation to intestine adhesion, suggesting its potential use as a permanent biomaterial for abdominal wall reconstruction. For the same reasons poly (vinyl chloride) by itself, particularly due to the lack of intestine adhesion after 9 weeks, may constitute in an efficient and low cost biomaterial for short term abdominal wall repair. In the case of anionic collagen coated polypropylene, the biological response was associated with an anomalous metaplastic ossification surrounding the polypropylene making the material improper for the purpose intended in this work. Although we do not have a plausible explanation for this anomalous tissue response, due to the well known good behavior of collagen implants, we think that this may be associated to the significant higher dielectric properties of anionic collagen in comparison to native collagen biomaterials. In vivo this property is closely related to bone tissue growth and remodeling. Acknowledgments: 2João Vicente de Paiva Neto, 2Domingos Zanchetta Netto and FAPESP. Apartado: Patología Experimental Palabras clave: polypropylene, poly (vinyl chloride), anionic collagen, abdominal wall, reconstruction, metaplastic ossification. Fecha recepción: 04/02/2001 Estado Comité Científico: Aceptado Fecha evaluación: NOTA: Para cualquier modificación del contenido de los Abstacts ya registrados, escribir por correo electrónico a la dirección mailto:conganat@uninet.edu consignado en el Asunto del mensaje su  referencia: PÓSTER-E / y la indicación:"MODIFICAR RESUMEN".