RESUMEN 84: INDUCTION OF ACTIVATION MARKERS ON ENDOMETRIOSIS VESICLES. I. Velasco, A. Campos, F. Quereda, M.J. Gómez-Torres Division of Immunology and Department of Obstetrics and Gynaecology of University Miguel Hernandez. Alicante, Spain. IV-CVHAP 2001 PÓSTER-E - 038 La versión electrónica completa de este trabajo podrá encontrarse on-line, una vez evaluado y aceptado, en la URL: http://conganat.uninet.edu/POSTER-E/038/ Abstract    INTRODUCTION: Rat Wistar has been used as a model to study endometriosis. It has not been well described the alterations on immune system associated to the endometriosis. In our experience, treatment with recombinant IL-2 has a clinical benefit on women with endometriosis. The aim of this study is know the effect of IL-2r on implantation and development of ectopic endometrium.  MATERIAL AND METHODS: Fifty Wistar rats were divided into four groups: a) no endometriosis; b) no endometriosis treated with intraperitoneal IL-2r; c) induced endometriosis; d) induced endometriosis treated with IL-2r. After 30 days, the rats were put on sleep and endometriotic vesicles were obtained. The tissue samples were sectioned and analysed by immunohistochemical staining with monoclonal antibodies.  RESULTS: We have observed an expression of CD25+, CD29+, CD80+, activated macrophages and dendritic cells on endometriotic vesicles from rats treated with IL-2r.  CONCLUSION: Treatment with IL-2r on experimental endometriosis induces the presence of activated cells in local lesion. That could explain an elevated production of proinflammatory cytokines observed in women with endometriosis. Apartado: Ginecopatología Palabras clave: endometriosis, IL-2 Fecha recepción: 01/02/2001 Estado Comité Científico: Aceptado Fecha evaluación: NOTA: Para cualquier modificación del contenido de los Abstacts ya registrados, escribir por correo electrónico a la dirección mailto:conganat@uninet.edu consignado en el Asunto del mensaje su  referencia: PÓSTER-E /038 y la indicación:"MODIFICAR RESUMEN".